alexa Inflammatory bowel disease associated with Yersinia enterocolitica O:3 infection.


Journal of Gastrointestinal & Digestive System

Author(s): Saebo A, Vik E, Lange OJ, Matuszkiewicz L

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Abstract BACKGROUND: Certain microorganisms may be associated with the development of inflammatory bowel disease (IBD). These pathogens may possess such properties as immunological capability or tissue invasiveness. An association between Yersinia enterocolitica infection and ulcerative colitis (UC) was suggested 30 years ago, and a connection with Crohn's disease (CD) may also exist. The aim of this study was to further elucidate the association between Y. enterocolitica O:3 infection and IBD. METHODS: During the period 1990-1997, antibody response against Y. enterocolitica was estimated in 1588 patients by tube agglutination. Forty-one patients with Y. enterocolitica infection (titer = 320) constituted the study group; 1041 patients without antibody response constituted the control group. The study was completed in 2003, after 6-13 years. RESULTS: At diagnosis of Y. enterocolitica infection, UC of acute onset was demonstrated in three males; another suffered from CD. At follow-up, two additional patients had developed UC and two CD. In the control group, 32 patients were diagnosed as having UC and 10 CD. This difference in IBD prevalence is significant (8/41>42/1041, p=0.00035), as were the differences in prevalence of UC and CD separately (p=0.006; viz. p<0.015). CONCLUSION: The present study supports the concept of the Y. enterocolitica infection as a trigger of chronic IBD. This article was published in Eur J Intern Med and referenced in Journal of Gastrointestinal & Digestive System

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