alexa Influence of (11)C-choline PET CT on the treatment planning for salvage radiation therapy in patients with biochemical recurrence of prostate cancer.


Journal of Nuclear Medicine & Radiation Therapy

Author(s): Souvatzoglou M, Krause BJ, Prschel A, Thamm R, Schuster T,

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Abstract BACKGROUND AND PURPOSE: The present study evaluates the incidence of (11)C-choline PET/CT positive findings in patients with recurrent prostate cancer referred for salvage radiotherapy (SRT) and the influence on the definition of the planning target volume (PTV). MATERIAL AND METHODS: Thirty-seven patients treated with radical prostatectomy and referred to SRT to the prostatic fossa because of biochemical relapse, were analysed retrospectively. All patients underwent (11)C-choline PET/CT before radiotherapy. The influence of PET/CT on the extent of the PTV was analysed. The median total follow up after SRT was 51.2 months. RESULTS: 11/37 (30\%) patients had a positive finding in the (11)C-choline PET/CT, 5 (13\%) outside of the prostatic fossa (iliac lymph nodes), implicating an extension of the PTV. Patients with positive (11)C-choline PET/CT had a significant higher PSA value than patients with no pathologic uptake (p=0.03). Overall, at the end of follow up 56\% of the patients had a PSA ≤ 0.2ng/ml and 44\% had a biochemical relapse of prostate cancer. CONCLUSIONS: (11)C-choline PET/CT detects abnormalities outside of the prostatic fossa in 13\% of patients referred for SRT because of biochemical relapse after radical prostatectomy, affecting the extent of the PTV. Prospective studies need to be implemented to evaluate the benefit of SRT with a PTV based on (11)C-choline PET/CT. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. This article was published in Radiother Oncol and referenced in Journal of Nuclear Medicine & Radiation Therapy

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