alexa Influence of dosage and timing of application of platelet-derived growth factor on early healing of the rat medial collateral ligament.
Physicaltherapy & Rehabilitation

Physicaltherapy & Rehabilitation

Journal of Sports Medicine & Doping Studies

Author(s): Batten ML, Hansen JC, Dahners LE

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Abstract In previous studies, platelet-derived growth factor has demonstrated beneficial in vivo effects on wound healing. We report the results of two studies of platelet-derived growth factor in the rat medial collateral ligament injury model. Experimental injury sites were implanted with platelet-derived growth factor, whereas contralateral controls received only collagen. Twelve days postoperatively, the femur-medial collateral ligament-tibia complex was tested mechanically. Our first study found a marked drop in the effectiveness of platelet-derived growth factor when it was administered more than 24 hours after injury. Dose-response testing showed maximum increases in strength (90\%) with 5.0 micrograms of platelet-derived growth factor, but the 1.0 microgram group showed similar strength increases, indicating a probable plateau effect in the response. These results indicate that platelet-derived growth factor has promise for healing ligaments but that it must be administered in appropriate doses soon after injury. This article was published in J Orthop Res and referenced in Journal of Sports Medicine & Doping Studies

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