alexa Influence of nutrients and other dietary materials on cytochrome P-450 enzymes.


Journal of Gerontology & Geriatric Research

Author(s): Guengerich FP

Abstract Share this page

Abstract The cytochrome P-450 (P-450) enzymes are collectively responsible for the bulk of oxidation of xenobiotic chemicals, including drugs, pesticides, and carcinogens. This biotransformation can result in either increased or decreased toxicity, depending on the situation. The regulation of individual P-450 enzymes is a complex subject, with examples of induction and direct inhibition and stimulation. Nutrients and food additives can modify P-450 activities and consequently influence toxicity. P-450s also influence the toxicity of potentially harmful materials found in foods, as well as some vitamins and natural products. Some of the foodstuffs and conditions that influence P-450 in experimental animals and in humans are protein, carbohydrate, lipid, obesity and fasting, water- and fat-soluble vitamins, minerals, sulfides, isothiocyanates, indoles, ellagic acid, capsaicin, terpenes, flavones, butylated hydroxytoluene and hydroxyanisole, charbroiled foods, ethanol, and (monosodium) glutamate and aspartate. Consideration is given, when possible, to differences in responses between animal models and humans.
This article was published in Am J Clin Nutr and referenced in Journal of Gerontology & Geriatric Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version