alexa Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Obesity & Weight Loss Therapy

Author(s): Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM

Abstract Share this page

Abstract Increased body weight is a strong risk factor for hypertension. A meta-analysis of randomized controlled trials was performed to estimate the effect of weight reduction on blood pressure overall and in population subgroups. Twenty-five randomized, controlled trials (comprising 34 strata) published between 1966 and 2002 with a total of 4874 participants were included. A random-effects model was used to account for heterogeneity among trials. A net weight reduction of -5.1 kg (95\% confidence interval [CI], -6.03 to -4.25) by means of energy restriction, increased physical activity, or both reduced systolic blood pressure by -4.44 mm Hg (95\% CI, -5.93 to -2.95) and diastolic blood pressure by -3.57 mm Hg (95\% CI, -4.88 to -2.25). Blood pressure reductions were -1.05 mm Hg (95\% CI, -1.43 to -0.66) systolic and -0.92 mm Hg (95\% CI, -1.28 to -0.55) diastolic when expressed per kilogram of weight loss. As expected, significantly larger blood pressure reductions were observed in populations with an average weight loss >5 kg than in populations with less weight loss, both for systolic (-6.63 mm Hg [95\% CI, -8.43 to -4.82] vs -2.70 mm Hg [95\% CI, -4.59 to -0.81]) and diastolic (-5.12 mm Hg [95\% CI, -6.48 to -3.75] vs -2.01 mm Hg [95\% CI, -3.47 to -0.54]) blood pressure. The effect on diastolic blood pressure was significantly larger in populations taking antihypertensive drugs than in untreated populations (-5.31 mm Hg [95\% CI, -6.64 to -3.99] vs -2.91 mm Hg [95\% CI, -3.66 to -2.16]). This meta-analysis clearly shows that weight loss is important for the prevention and treatment of hypertension. This article was published in Hypertension and referenced in Journal of Obesity & Weight Loss Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 13th World Congress on Obesity
    Aug 24-25, 2017, Toronto, Canada
  • 13th Euro Obesity and Endocrinology Congress
    Sep 21-23, 2017, Madrid, Spain
  • 14th Global Obesity Meeting
    Oct 23-24, 2017 Dubai, UAE
  • 16th International Conference and Exhibition on Obesity & Weight Management
    November 13-15, 2017 Atlanta,Georgia, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version