alexa Infrapopliteal angioplasty for critical limb ischemia: relation of TransAtlantic InterSociety Consensus class to outcome in 176 limbs.
Healthcare

Healthcare

Journal of Health Education Research & Development

Author(s): Giles KA, Pomposelli FB, Spence TL, Hamdan AD, Blattman SB,

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Abstract OBJECTIVE: Recent data suggest that percutaneous transluminal angioplasty (PTA) may be appropriate primary therapy for critical limb ischemia (CLI). However, little data are available regarding infrapopliteal angioplasty outcomes based on TransAtlantic InterSociety Consensus (TASC) classification. We report our experience with infrapopliteal angioplasty stratified by TASC lesion classification. METHODS: From February 2004 to March 2007, 176 consecutive limbs (163 patients) underwent infrapopliteal angioplasty for CLI. Stents were placed for lesions refractory to PTA or flow-limiting dissections. Patients were stratified by TASC classification and suitability for bypass grafting. Primary outcome was freedom from restenosis, reintervention, or amputation. Primary patency, freedom from secondary restenosis, limb salvage, reintervention by repeat angioplasty or bypass, and survival were determined. RESULTS: Median age was 73 years (range, 39-94 years). Technical success was 93\%. Average follow-up was 10 months (range, 1-41 months). At 1 and 2 years, freedom from restenosis, reintervention, or amputation was 39\% and 35\%, conventional primary patency was 53\% and 51\%, and freedom from secondary restenosis and reintervention were 63\% and 61\%, respectively. Limb salvage was 84\% at 1, 2, and 3 years. Within 2 years, 15\% underwent bypass and 18\% underwent repeat infrapopliteal PTA. Postoperative complications occurred in 9\% and intraprocedural complications in 10\%. The 30-day mortality was 5\% (9 of 181). Overall survival was 81\%, 65\%, and 54\% at 1, 2, and 3 years. TASC D classification predicted diminished technical success (75\% D vs 100\% A, B, and C; P < .001), primary restenosis, reintervention, or amputation (hazard ratio [HR], 3.4; 95\% confidence interval [CI], 2.1-5.5, P < .001), primary patency (HR, 2.2; 95\% CI, 1.3-3.9, P < .004), secondary restenosis (HR, 3.2; 95\% CI, 1.6-6.4, P = .001), and limb salvage (HR, 2.6; 95\% CI, 1.1-6.3, P < .05). Unsuitability for surgical bypass also predicted restenosis, reintervention, or amputation, secondary restenosis, need for repeated angioplasty, and inferior primary patency and limb salvage rates. CONCLUSION: Infrapopliteal angioplasty is a reasonable primary treatment for CLI patients with TASC A, B, or C lesions. Restenosis, reintervention, or amputation was higher in patients who were unsuitable candidates for bypass; however, an attempt at PTA may be indicated as an alternative to primary amputation. Although restenosis, reintervention, or amputation is high after tibial angioplasty for CLI, excellent limb salvage rates may be obtained with careful follow-up and reinterventions when necessary, including bypass in 15\%. This article was published in J Vasc Surg and referenced in Journal of Health Education Research & Development

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