alexa Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?


Biochemistry & Analytical Biochemistry

Author(s): Mitsakos V, Dobson RC, Pearce FG, Devenish SR, Evans GL,

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Abstract Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable. This article was published in Bioorg Med Chem Lett and referenced in Biochemistry & Analytical Biochemistry

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