alexa Inhibition of angiogenesis by vitamin D3 analogues.


Journal of Clinical & Experimental Dermatology Research

Author(s): Oikawa T, Hirotani K, Ogasawara H, Katayama T, Nakamura O,

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Abstract The effects of vitamin D3 and two analogues on embryonic angiogenesis were studied in 4.5-day-old chick embryo chorioallantoic membranes. The active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3, and a synthetic vitamin D3 analogue, 22-oxa-1 alpha,25-dihydroxyvitamin D3, inhibited angiogenesis in a dose-dependent manner, the inhibition occurring in the picomolar range. In contrast, vitamin D3 was not effective. The results suggest that these two vitamin D3 analogues might be promising anti-angiogenic agents for controlling the angiogenesis which occurs in several pathological conditions, including tumor development.
This article was published in Eur J Pharmacol and referenced in Journal of Clinical & Experimental Dermatology Research

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