alexa Inhibition of aromatase activity by flavonoids.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Jeong HJ, Shin YG, Kim IH, Pezzuto JM

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Abstract In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50\% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 microg/mL), chrysin (IC50: 1.1 microg/mL), and hesperetin (IC50: 1.0 microg/mL).
This article was published in Arch Pharm Res and referenced in Biochemistry & Analytical Biochemistry

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