alexa Inhibition of aspartate transcarbamylase by a phenobarbital derivative.


Biochemistry & Physiology: Open Access

Author(s): Balbaa M, Yacout G, Ghonaim T, Othman D

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Abstract Mammalian and hepatic aspartate transcarbamylase is inhibited by phenobarbital p-nitrophenylhydrazone in a reversible and non-competitive type with Ki values 8.45 x 10(-5) and 9.64 x 10(-5) M in the reactions toward carbamyl phosphate and aspartate, respectively. In vivo inhibition occurred in a dose-dependent manner in which less than 50\% of the activity was retained. These observations suggest that this inhibitor may interfere with the in vivo regulation of this enzyme and lead to an additional biological effect of phenobarbitals.
This article was published in J Enzyme Inhib and referenced in Biochemistry & Physiology: Open Access

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