alexa Inhibition of influenza and parainfluenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA)


Journal of Antivirals & Antiretrovirals

Author(s): Palese P

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A synthetic analog of neuraminic acid, 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA) is a potent specific inhibitor of neuraminidase. This compound inhibits the elution of influenza viruses from erythrocytes, and causes a marked reduction in the size of plaques produced by influenza A viruses and NDV in cell culture under agar overlay. In a single step growth cycle of WSN virus in MDBK cells FANA has only a marginal inhibitory effect, but during multicycle replication in the same virus-cell system FANA produces a marked reduction in the yield of virus. Replication of VSV virus which does not contain neuraminidase is not affected by this compound, suggesting that its inhibitory effect on the replication of influenza and parainfluenza viruses is mediated by specific inhibition of viral neuraminidase activity.

This article was published in J Gen Virol and referenced in Journal of Antivirals & Antiretrovirals

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