Author(s): Zhao WH, Hu ZQ, Hara Y, Shimamura T
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Abstract The combination of epigallocatechin gallate (EGCg, a main constituent of tea catechins) with penicillin showed synergism against 21 clinical isolates of penicillinase-producing Staphylococcus aureus. Besides binding directly to peptidoglycan, the inhibition of penicillinase activity by EGCg is responsible for the synergism. EGCg inhibited the penicillinase activity in a dose-dependent fashion, with a 50\% inhibitory concentration of 10 microg/ml.
This article was published in Antimicrob Agents Chemother
and referenced in Journal of Antivirals & Antiretrovirals