alexa Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.


Journal of Clinical & Cellular Immunology

Author(s): Taylor DR, Shi ST, Romano PR, Barber GN, Lai MM

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Abstract Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2alpha, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.
This article was published in Science and referenced in Journal of Clinical & Cellular Immunology

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