alexa Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism.
Gastroenterology

Gastroenterology

Journal of Gastrointestinal & Digestive System

Author(s): Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M,

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Abstract Commensal bacteria in the lower intestine of mammals are 10 times as numerous as the body's cells. We investigated the relative importance of different immune mechanisms in limiting the spread of the intestinal microbiota. Here, we reveal a flexible continuum between innate and adaptive immune function in containing commensal microbes. Mice deficient in critical innate immune functions such as Toll-like receptor signaling or oxidative burst production spontaneously produce high-titer serum antibodies against their commensal microbiota. These antibody responses are functionally essential to maintain host-commensal mutualism in vivo in the face of innate immune deficiency. Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms of inflammatory diseases where immune dysfunction is implicated.
This article was published in Science and referenced in Journal of Gastrointestinal & Digestive System

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