Author(s): Beutler B, Rietschel ET
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Abstract How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors--the Toll-like receptors--was rooted in chemical, biological and genetic analyses that centred on a bacterial poison, termed endotoxin.
This article was published in Nat Rev Immunol
and referenced in Clinical Microbiology: Open Access