Author(s): Moenner M, Pluquet O, Bouchecareilh M, Chevet E, Moenner M, Pluquet O, Bouchecareilh M, Chevet E
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Abstract The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation, particularly in the unfolded protein response, which is being found to play a major role in cancer and many other diseases. Here, we address ER-mediated signaling and regulations in the context of environmental challenges in cancer, such as hypoxia, angiogenesis, and chemotherapeutic resistance, and we discuss how ER-resident molecular machines become deregulated and involved in cancer-related pathology. Further exploration of how the ER senses, signals, and adapts to stress may redefine and deepen our understanding of its functions in cancer pathobiology.
This article was published in Cancer Res
and referenced in Dermatology and Dermatologic Diseases