alexa Integrating cell-signalling pathways with NF-kappaB and IKK function.
Toxicology

Toxicology

Journal of Clinical Toxicology

Author(s): Perkins ND

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Abstract Nuclear factor (NF)-kappaB and inhibitor of NF-kappaB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-kappaB or IKK function contributes to many human diseases, including cancer. However, the NF-kappaB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate. This article was published in Nat Rev Mol Cell Biol and referenced in Journal of Clinical Toxicology

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