alexa Integrating diverse genomic data using gene sets.
Genetics

Genetics

Advancements in Genetic Engineering

Author(s): Tyekucheva S, Marchionni L, Karchin R, Parmigiani G

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Abstract We introduce and evaluate data analysis methods to interpret simultaneous measurement of multiple genomic features made on the same biological samples. Our tools use gene sets to provide an interpretable common scale for diverse genomic information. We show we can detect genetic effects, although they may act through different mechanisms in different samples, and show we can discover and validate important disease-related gene sets that would not be discovered by analyzing each data type individually.
This article was published in Genome Biol and referenced in Advancements in Genetic Engineering

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