alexa Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells.


Journal of Cancer Science & Therapy

Author(s): Abboud ER, Coffelt SB, Figueroa YG, Zwezdaryk KJ, Nelson AB,

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Abstract Based on cDNA microarray results, integrin-linked kinase (ILK) emerged as an interesting candidate in hypoxia-mediated survival mechanisms employed by cancer cells. This notion was confirmed here by the following observations: the 5' promoter region of the ilk gene contains hypoxia responsive elements (HRE) that bind hypoxia-inducible factor (HIF) transcription factor complexes and drive HRE-luciferase gene expression in reporter assays; ILK protein and kinase activity are induced following hypoxia; downstream targets of ILK signaling are induced following hypoxia treatment; inhibition of ILK leads to increased apoptosis; and HIF and ILK are co-localized within human cancer tissues. The identification of ILK as a player in hypoxia survival signaling employed by cancer cells further validates ILK as a unique target for cancer therapy.
This article was published in Int J Oncol and referenced in Journal of Cancer Science & Therapy

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