alexa Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance.
Immunology

Immunology

Immunochemistry & Immunopathology

Author(s): Seguin L, Desgrosellier JS, Weis SM, Cheresh DA

Abstract Share this page

Abstract Interactions between cancer cells and their surroundings can trigger essential signaling cues that determine cell fate and influence the evolution of the malignant phenotype. As the primary receptors involved in cell-matrix adhesion, integrins present on the surface of tumor and stromal cells have a profound impact on the ability to survive in specific locations, but in some cases, these receptors can also function in the absence of ligand binding to promote stemness and survival in the presence of environmental and therapeutic stresses. Understanding how integrin expression and function is regulated in this context will enable the development of new therapeutic approaches to sensitize tumors to therapy and suppress their metastatic phenotype. Copyright © 2014 Elsevier Ltd. All rights reserved.
This article was published in Trends Cell Biol and referenced in Immunochemistry & Immunopathology

Relevant Expert PPTs

Relevant Speaker PPTs

  • Alexandra Emelyanova
    Released-active antibodies are innovative products for the effective management of severe respiratory viral infections
    PPT Version | PDF Version
  • Moshe Giladi
    Tumor Treating Fields (TTFields) induced cancer cell death may be immunogenic resulting in enhanced antitumor efficacy when combined with immune-modulating therapy
    PPT Version | PDF Version
  • Mohamed Elchalakani
    Mohamed Elchalakani-Dubai-Men’s-College-UAE-CFRP-Strengthening-and-Rehabilitation-of-Corroded-Steel-Pipelines-Under-Combined-Bending-and-Bearing
    PPT Version | PDF Version
  • Shuk-Man Ka
    Renoprotective effects of citral on accelerated and severe lupus nephritis mice by inhibiting activation signal of NLRP3 inflammasome and enhancing Nrf2 activation
    PPT Version | PDF Version
  • Osama A Fekry
    Impact of nutritional modification on Egyptian patients with fatty liver combined with HCV
    PPT Version | PDF Version
  • Etakula Nagabhushan
    Studies on the Combined Effect of Multi – Walled Carbon Nano Tubes (MWCNTs) and Maleic Anhydride grafted Polypropylene (MA – g PP) on the Mechanical and Thermal Properties of Polypropylene (PP)
    PPT Version | PDF Version
  • Juliann G. Kiang
    Bone marrow mesenchymal stem cells increases survival after ionizing irradiation combined with wound trauma
    PPT Version | PDF Version
  • Fulvia Seccareccia
    Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis: Results from an intermediate risk propensity-matched population of the Italian OBSERVANT Study
    PDF Version

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords