alexa Interaction of citrus juices with felodipine and nifedipine.
Chemistry

Chemistry

Medicinal Chemistry

Author(s): Bailey DG, Spence JD, Munoz C, Arnold JM

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Abstract Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice. The mean felodipine bioavailability with grapefruit juice was 284 (range 164-469)\% of that with water. The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water. Vasodilatation-related side-effects were more frequent. Orange juice had no such effects. Six healthy men took nifedipine 10 mg with water or grapefruit juice; the bioavailability with grapefruit juice was 134 (108-169)\% of that with water.
This article was published in Lancet and referenced in Medicinal Chemistry

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