Author(s): Yanyan L, Yanyan L
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Abstract BACKGROUND: The intercellular adhesion molecule-1 (ICAM-1) E469K gene polymorphism has been implicated in increased coronary artery disease (CAD) susceptibility, but the individual study results are still controversial. HYPOTHESIS: The ICAM-1 E469K gene polymorphism may be associated with CAD risk. METHODS: The current meta-analysis involving 3065 subjects and 11 separate studies was conducted to explore the relationship between the ICAM-1 E469K gene polymorphism and CAD in the Chinese population. The pooled odds ratio (ORs) for the distribution of K allele frequency of ICAM-1 E469K gene and its corresponding 95\% confidence interval (CI) was assessed by random effect model. RESULTS: The distribution of the K allele frequency was 0.67 for the CAD group and 0.60 for the control group. The pooled OR for the distribution of the K allele frequency of the ICAM-1 E469K gene was 1.32 (95\% CI, 1.02-1.72; P(heterogeneity) < 0.00001; inconsistency index I(2) = 81.8\%). The association between the ICAM-1 E469K gene polymorphism and CAD in the Chinese population was significant (P = 0.04). CONCLUSIONS: In the Chinese population, the distribution of the K allele frequency of the ICAM-1 E469K gene was indicated to be associated with CAD risk. The K allele of the ICAM-1 E469K gene might predispose to the CAD susceptibility. © 2011 Wiley Periodicals, Inc.
This article was published in Clin Cardiol
and referenced in Immunome Research