alexa Interleukin-11, interleukin-1beta, interleukin-12 and the pathogenesis of inflammatory periodontal diseases.
Immunology

Immunology

Immunome Research

Author(s): Ycel OO, Berker E, Garibolu S, Otlu H

Abstract Share this page

OBJECTIVES: The balance between pro-inflammatory and anti-inflammatory cytokines may be crucial for determining the immunopathology of gingivitis (G) and periodontitis. This study aimed to analyse interleukin-1beta (IL-1beta), IL-11 and IL-12 levels in gingival crevicular fluid (GCF) of patients with G and chronic periodontitis (CP). MATERIAL AND METHODS: Fourty subjects including 12 CP, 14 G and 14 controls (C) were enrolled. GCF samples were collected from six maxillary sites per patient and analysed for IL-1beta, IL-11 and IL-12 by an enzyme-linked immunosorbent assay. RESULTS: Significantly lower concentrations of IL-11 were detected in CP compared with both G and C groups (p<0.05). The CP group had a significantly higher total amount of IL-12 and IL-1beta compared with the C group (p<0.05). The IL-11:IL-1beta cytokine ratio was higher in both G and C groups compared with the CP group. The IL-11:IL-1beta ratio became progressively lower with increasing probing depth (p<0.01). CONCLUSIONS: Our data showed that IL-11 levels are significantly decreased in GCF from sites with periodontitis compared with G and healthy sites. Because of the possible preventive effect of IL-11 on inflammation, IL-11 may be an important factor in the therapeutic modulation of periodontal disease.

This article was published in J Clin Periodontol. and referenced in Immunome Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords