Author(s): Babaloo Z, Kaye PM, Eslami MB
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Abstract The role of interleukin (IL)-13, a Th2 cytokine sharing many of the features of IL-4, has not previously been examined in patients with visceral leishmaniasis (VL). We examined sera from Iranian patients with VL caused by Leishmania infantum. Serum IL-13 was detected in 50\% (22/44) of patients with active primary disease. In comparison, IL-10 was detected in 79.5\% (35/44), interferon gamma (IFN gamma) in 38.5\% (17/44), and IL-4 in only 5\% (2/44) of these patients. With few exceptions all 3 cytokines were undetectable after clinical recovery following antimony therapy. Five of 7 patients (71\%) who failed antimony therapy and had relapsing disease had similar levels of IL-10 to patients with active primary disease. However, with only 1 exception, IL-13, IFN gamma and IL-4 were not detected in such patients. These data suggest that relapsing disease may result from defective cellular immunity, unrelated to immunosuppression mediated by IL-10.
This article was published in Trans R Soc Trop Med Hyg
and referenced in Journal of Vaccines & Vaccination