alexa Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus.
Neurology

Neurology

Journal of Alzheimers Disease & Parkinsonism

Author(s): Tancredi V, Zona C, Velotti F, Eusebi F, Santoni A

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Abstract The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.
This article was published in Brain Res and referenced in Journal of Alzheimers Disease & Parkinsonism

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