Author(s): Stolfi C, Pallone F, Macdonald TT, Monteleone G
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Abstract Interleukin (IL)-21, a cytokine produced by activated conventional CD4+ T lymphocytes and Natural Killer T cells, drives anti-tumor immunity in the skin and kidney. However IL-21 is also pro-inflammatory in many tissues and promotes colitis-associated colon cancer. Understanding the biology of IL-21 in these different situations is needed to ensure maximal therapeutic benefit.
This article was published in Oncoimmunology
and referenced in Journal of Clinical & Cellular Immunology