alexa Interruption of the rat circadian clock by short light-dark cycles.


Neurochemistry & Neuropharmacology

Author(s): Usui S, Okazaki T, Honda Y

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Abstract Ninety male Sprague-Dawley rats were exposed to 1:1-h light-dark (LD1:1) cycles for 50-90 days, and then they were released into constant darkness (DD). During LD1:1 cycles, behavioral rhythms were gradually disintegrated, and circadian rhythms of locomotor activity, drinking, and urine 6-sulfatoxymelatonin excretion were eventually abolished. After release into DD, 44 (49\%) rats showed arrhythmic behavior for >10 days. Seven (8\%) animals that remained arrhythmic for >50 days in DD were exposed to brief light pulses or 12:12-h light-dark cycles, and then they restored their circadian rhythms. These results indicate that the circadian clock was stopped, at least functionally, by LD1:1 cycles and was restarted by subsequent light stimulation. This article was published in Am J Physiol Regul Integr Comp Physiol and referenced in Neurochemistry & Neuropharmacology

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