Author(s): Maiuri F, Iaconetta G, Benvenuti D, Lamaida E, De Caro ML
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Abstract A case of meningeal melanocytoma of the left sphenoid wing is reported and the other nine cases in the literature are reviewed. Meningeal melanocytoma is a benign melanotic tumor that derives from the melanocytes of the leptomeninges and may occur anywhere in the cranial and spinal meninges. Electron microscopy well demonstrates melanin and melanosomes within the tumor cells. The immunohistochemical pattern of this tumor includes strong positivity for S-100 protein, vimentin, and antimelanoma antibody and negativity for epithelial membrane antigen, neuron-specific enolase, cytokeratin, and glial fibrillary acidic protein. Complete surgical removal is the treatment of choice, whereas radiotherapy is usually unnecessary. In spite of benign biologic behavior of meningeal melanocytoma, the prognosis remains uncertain, because of the possible local recurrences.
This article was published in Surg Neurol
and referenced in Journal of Pigmentary Disorders