alexa Intramacrophage antimicrobial effect of silver nanoparticles against Brucella melitensis 16M


Journal of Bacteriology & Parasitology

Author(s): H Alizadeh, M Salouti, R Shapouri

Abstract Share this page

Brucellosis is a zoonosis disease of worldwide importance among animal and humans. The most important virulence factor of Brucella spp. is related to its intramachrophage survival. On the other hand, because of the side effects of the current brucellosis treatment regime, it is necessary to find out new antimicrobial agents to treat the disease. The aim of this study is to investigate the antibacterial effect of silver nanoparticles against Brucella under an intramacrophage condition. A well diffusion agar test showed the activity of silver nanoparticles against Brucella melitensis 16M. Macrodilution experiments demonstrated the MIC and MBC of silver nanoparticles 4 and 6 ppm, respectively. The incubation time study showed that silver nanoparticles were able to kill bacteria within 40 min after the reaction. The cell culture study revealed that silver nanoparticles have effective antimicrobial activity inside the macrophage cells in concentrations of 4–6 ppm and the findings showed that one may consider silver nanoparticles as a new nano drug against intramachrophage Brucella melitensis 16M.

This article was published in Scientia Iranica and referenced in Journal of Bacteriology & Parasitology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version