Author(s): Bjrkstn B, Finnstrm O, Wichman K
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Abstract Cord blood IgE levels and the development of allergy were studied in 29 children born by mothers who had been treated with the beta-adrenergic receptor blocking agent, metoprolol, during the pregnancy and in 23 children of placebo-treated mothers. In 13 (45\%) of the former and 3 (15\%) of the placebo group elevated cord blood IgE levels, i.e. more than 0.9 kU/l and/or obvious or probable allergy developed (p = 0.03). The findings support previous experimental observations that beta-blocking agents may enhance IgE antibody formation. It also adds to the number of environmental factors that may increase the risk for atopic disease in children.
This article was published in Int Arch Allergy Appl Immunol
and referenced in Journal of Nutritional Disorders & Therapy