Author(s): Olson JL, Courtney RJ, Rouhani B, Mandava N, Dinarello CA
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Abstract PURPOSE: To determine the effect of intravitreal anakinra on choroidal neovascularization (CNV) in an animal model. METHODS: Laser photocoagulation used to rupture Bruch's membrane; animals then assigned to groups based on varying frequency of intravitreal anakinra injections. At day 30, digital angiography was used to measure the CNV area. RESULT: Intravitreal anakinra dose-dependently inhibited CNV growth. Injections given one time resulted in a 26\% reduction in CNV; in the once weekly group, a 41\% reduction was seen; in the twice-weekly group, a 62\% reduction was seen (all p < .001). CONCLUSION: Suppressing IL-1 function may provide another therapeutic avenue in exudative AMD.
This article was published in Ocul Immunol Inflamm
and referenced in Journal of Clinical & Experimental Ophthalmology