alexa Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model.


Journal of Clinical & Experimental Ophthalmology

Author(s): Olson JL, Courtney RJ, Rouhani B, Mandava N, Dinarello CA

Abstract Share this page

Abstract PURPOSE: To determine the effect of intravitreal anakinra on choroidal neovascularization (CNV) in an animal model. METHODS: Laser photocoagulation used to rupture Bruch's membrane; animals then assigned to groups based on varying frequency of intravitreal anakinra injections. At day 30, digital angiography was used to measure the CNV area. RESULT: Intravitreal anakinra dose-dependently inhibited CNV growth. Injections given one time resulted in a 26\% reduction in CNV; in the once weekly group, a 41\% reduction was seen; in the twice-weekly group, a 62\% reduction was seen (all p < .001). CONCLUSION: Suppressing IL-1 function may provide another therapeutic avenue in exudative AMD. This article was published in Ocul Immunol Inflamm and referenced in Journal of Clinical & Experimental Ophthalmology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version