Author(s): Madeo F, Kroemer G
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Abstract Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.
This article was published in Mol Cell
and referenced in Journal of Aquaculture Research & Development