alexa Intrinsic defect of the immune system in children with Down syndrome: a review.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Thyroid Disorders & Therapy

Author(s): Kusters MA, Verstegen RH, Gemen EF, de Vries E, Kusters MA, Verstegen RH, Gemen EF, de Vries E

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Abstract Down syndrome (DS) is the most frequent cause of mental retardation in man. Immunological changes in DS have been observed since the 1970s. The neurological system appears to be ageing precociously, with early occurrence of Alzheimer disease; until now, the observed immunological differences have been interpreted in the same context. Looking back at past and present results of immunological studies in DS children in relation to the clinical consequences they suffer, we conclude that it is more likely that the DS immune system is intrinsically deficient from the very beginning.
This article was published in Clin Exp Immunol and referenced in Journal of Thyroid Disorders & Therapy

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