alexa Involvement of tyrosine kinase-2 in both the IL-12 Th1 and IL-23 Th17 axes in vivo.


Journal of Clinical & Cellular Immunology

Author(s): Ishizaki M, Akimoto T, Muromoto R, Yokoyama M, Ohshiro Y,

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Abstract Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental diseases, including methylated BSA injection-induced footpad thickness, imiquimod-induced psoriasis-like skin inflammation, and dextran sulfate sodium- or 2,4,6-trinitrobenzene sulfonic acid-induced colitis. In these disease models, Tyk2 deficiency influenced the phenotypes in immunity and/or inflammation. Our findings demonstrate a somewhat broader contribution of Tyk2 to immune systems than previously expected and suggest that Tyk2 may represent an important candidate for drug development by targeting both the IL-12/Th1 and IL-23/Th17 axes. This article was published in J Immunol and referenced in Journal of Clinical & Cellular Immunology

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