alexa Iodide organification defect in a cold thyroid nodule: absence of iodide effect on cyclic AMP accumulation.
Diabetes & Endocrinology

Diabetes & Endocrinology

Endocrinology & Metabolic Syndrome

Author(s): DemeesterMirkine N, Van Sande J, Dor P, Heimann R, Cochaux P,

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Abstract A follicular adenoma of the thyroid was 'hot' one hour after 99mTc pertechnetate administration, but 'cold' 24 h after 131I iodide administration. Incubation of the tissue in vitro demonstrated a defect in iodide binding to proteins that was abolished by addition of an H2O2 generating system. In this tissue iodide failed to inhibit TSH-induced cyclic AMP accumulation. The results show that iodide oxidation is required for its inhibitory action on cyclic AMP accumulation in human thyroid.
This article was published in Clin Endocrinol (Oxf) and referenced in Endocrinology & Metabolic Syndrome

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