alexa Ion channels as pharmacologic receptors: the chirality of drug interactions.
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Triggle DJ

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Abstract Ion channels are pharmacologic receptors and as such exhibit stereoselective interactions with drugs. Ion channels are conformationally mobile transmembrane proteins existing in a number of open and closed states. Drug interactions with these different states may differ quantitatively and qualitatively. Stereoselectivity may not be a constant factor and may change according to channel state as determined by stimulus mode or experimental conditions. Selected examples are cited for Na+ and Ca2+ channels. This article was published in Chirality and referenced in Biochemistry & Analytical Biochemistry

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