alexa Ipilimumab-induced necrotic myelopathy in a patient with metastatic melanoma: A case report and review of literature.
Immunology

Immunology

Immunome Research

Author(s): Abdallah AO, Herlopian A, Ravilla R, Bansal M, ChandraReddy S

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Ipilimumab is a novel humanized monoclonal antibody directed against cytotoxic T lymphocyte antigen 4, a T-cell surface molecule involved in down-regulation and suppression of the T cell response to stimuli. Patients treated with ipilimumab are at risk for immune-related adverse events involving the skin, digestive tract, liver and endocrine organs. Few case reports of immune-related adverse effects involving central or peripheral nervous system due to ipilimumab are published. These include inflammatory myopathy, aseptic meningitis, severe meningo-radiculo-neuritis, temporal arteritis, Guillain-Barre syndrome, and posterior reversible encephalopathy syndrome. We report the first case of ipilimumab-induced progressive necrotic myelopathy.

This article was published in J Oncol Pharm Pract and referenced in Immunome Research

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