Author(s): Cardenas VM, Mulla ZD, Ortiz M, Graham DY
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Abstract Using data from the current National Health and Nutrition Examination Survey (1999-2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and iron-deficiency anemia (IDA) in the United States. Iron deficiency was defined as at least two abnormal results out of three biomarkers of iron stores. IDA was defined as a low hemoglobin level in the presence of iron deficiency. H. pylori infection was measured by serology. Complex survey estimators were used in the analysis. For 7,462 survey participants aged >or=3 years, H. pylori infection was associated with decreased serum ferritin levels (percent change = -13.9\%, 95\% confidence interval (CI): -19.5, -8.0) but not with levels of free erythrocyte protoporphyrin, transferrin saturation, or hemoglobin (percent change = 1.5\%, -2.8\%, and -1.1\%, respectively). Multinomial logistic regression analyses indicated that H. pylori infection was associated with the prevalence of IDA (prevalence odds ratio (POR) = 2.6, 95\% CI: 1.5, 4.6) and, to a lesser degree, other types of anemia (POR = 1.3, 95\% CI: 1.0, 1.7). H. pylori infection was associated with a 40\% increase in the prevalence of iron deficiency (POR = 1.4, 95\% CI: 0.9, 2.0) after controlling for relevant covariates. In the United States, H. pylori infection was associated with iron deficiency/IDA regardless of the presence or absence of peptic ulcer disease.
This article was published in Am J Epidemiol
and referenced in Biology and Medicine