Author(s): Shafi D, Purandare SV, Sathe AV
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Abstract OBJECTIVES: The aim of this study was to compare the efficacy and safety of intravenous iron with oral iron in the treatment of iron deficiency anemia of pregnancy. METHODS: A randomized experimental study was conducted at K. J. Somaiya Hospital involving 200 pregnant women with iron deficiency anemia. In the intravenous group iron dose was calculated from: Total iron dose required (mg) = 2.4 × weight kg × target hemoglobin - actual hemoglobin) g/dl + 500. Target hemoglobin was set at 12 g/dl. In the oral group patients received 200 mg oral ferrous ascorbate daily. Hemoglobin and serum ferritin were reviewed at 2, 4, and 6 weeks. Paired and independent t test was applied. RESULTS: The change in hemoglobin and ferritin levels from baseline was significantly higher in the intravenous group than the oral group at each measurement (P = 0.000). CONCLUSION: Intravenous iron elevates hemoglobin and restores iron stores faster than oral iron, with no severe adverse reactions.
This article was published in J Obstet Gynaecol India
and referenced in Journal of Blood Disorders & Transfusion