Author(s): Arin KK, Vanham G, Arts EJ, Arin KK, Vanham G, Arts EJ
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Abstract During the rapid spread of HIV-1 in humans, the main (M) group of HIV-1 has evolved into ten distinct subtypes, undergone countless recombination events and diversified extensively. The impact of this extreme genetic diversity on the phenotype of HIV-1 has only recently become a research focus, but early findings indicate that the dominance of HIV-1 subtype C in the current epidemic might be related to the lower virulence of this subtype compared with other subtypes. Here, we explore whether HIV-1 has reached peak virulence or has already started the slow path to attenuation.
This article was published in Nat Rev Microbiol
and referenced in Journal of AIDS & Clinical Research