alexa Is Zn2+ transported by the mitochondrial calcium uniporter?


Biochemistry & Analytical Biochemistry

Author(s): Saris NE, Niva K

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Abstract Zinc ions were found to inhibit Ca2+ uptake by rat liver mitochondria driven by succinate respiration but not that by a valinomycin-induced membrane potential. Zn2+ at 1 microM or higher concentrations induced a lowering of the membrane potential under the former but not the latter conditions. It is concluded that it is the lowered membrane potential in the presence of Zn2+ that reduces the rate of respiration-driven Ca2+. Ruthenium red was found to inhibit the uptake of Zn2+ but had no influence on its action upon the membrane potential. Zn2+ did not affect the Ruthenium red-insensitive Ca2+ efflux. Ca2+ stimulated the uptake of Zn2+. It is concluded that Zn2+ may be transported by the mitochondrial calcium uniporter but that it may have access to sites required for inhibition of respiration by other routes.
This article was published in FEBS Lett and referenced in Biochemistry & Analytical Biochemistry

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