alexa Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes.
Immunology

Immunology

Immunome Research

Author(s): Donath MY, BniSchnetzler M, Ellingsgaard H, Ehses JA, Donath MY, BniSchnetzler M, Ellingsgaard H, Ehses JA

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Abstract Onset of Type 2 diabetes occurs when the pancreatic beta-cell fails to adapt to the increased insulin demand caused by insulin resistance. Morphological and therapeutic intervention studies have uncovered an inflammatory process in islets of patients with Type 2 diabetes characterized by the presence of cytokines, immune cells, beta-cell apoptosis, amyloid deposits, and fibrosis. This insulitis is due to a pathological activation of the innate immune system by metabolic stress and governed by IL-1 signaling. We propose that this insulitis contributes to the decrease in beta-cell mass and the impaired insulin secretion observed in patients with Type 2 diabetes. This article was published in Physiology (Bethesda) and referenced in Immunome Research

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