alexa i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion.


Journal of Plant Biochemistry & Physiology

Author(s): Varlamov O, Volchuk A, Rahimian V, Doege CA, Paumet F,

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Abstract A new functional class of SNAREs, designated inhibitory SNAREs (i-SNAREs), is described here. An i-SNARE inhibits fusion by substituting for or binding to a subunit of a fusogenic SNAREpin to form a nonfusogenic complex. Golgi-localized SNAREs were tested for i-SNARE activity by adding them as a fifth SNARE together with four other SNAREs that mediate Golgi fusion reactions. A striking pattern emerges in which certain subunits of the cis-Golgi SNAREpin function as i-SNAREs that inhibit fusion mediated by the trans-Golgi SNAREpin, and vice versa. Although the opposing distributions of the cis- and trans-Golgi SNAREs themselves could provide for a countercurrent fusion pattern in the Golgi stack, the gradients involved would be strongly sharpened by the complementary countercurrent distributions of the i-SNAREs.
This article was published in J Cell Biol and referenced in Journal of Plant Biochemistry & Physiology

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