alexa Isolated tramadol overdose associated with Brugada ECG pattern.
Toxicology

Toxicology

Journal of Clinical Toxicology

Author(s): JON B COLE, SRINIVASAN SATTIRAJU, ELISABETH F BILDEN, RICHARD W ASINGER, STEFAN C BERTOG

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Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication.

This article was published in Pacing Clin Electrophysiol. and referenced in Journal of Clinical Toxicology

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