alexa Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis.


Biochemistry & Physiology: Open Access

Author(s): Lerner EA, Ribeiro JM, Nelson RJ, Lerner MR

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Abstract Blood feeding by the sand fly Lutzomyia longipalpis is aided by the presence of a vasodilator in its salivary glands. This novel vasodilator has been isolated by reversed-phase high-performance liquid chromatography. Ten nanograms of the vasodilator are present in the extract of a pair of sand fly salivary glands. It has 500 times the vasodilatory activity of calcitonin gene-related peptide, previously the most potent vasodilator peptide known. This novel peptide is thus called maxadilan.
This article was published in J Biol Chem and referenced in Biochemistry & Physiology: Open Access

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