alexa Iterative in situ click chemistry creates antibody-like protein-capture agents.
Chemical Engineering

Chemical Engineering

Journal of Analytical & Bioanalytical Techniques

Author(s): Agnew HD, Rohde RD, Millward SW, Nag A, Yeo WS,

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Abstract Special agents for protein capture: Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one-bead-one-compound method for the creation of a peptide library enable the fragment-based assembly of selective high-affinity protein-capture agents. The resulting ligands are water-soluble and stable chemically, biochemically, and thermally. They can be produced in gram quantities through copper(I)-catalyzed cycloaddition.
This article was published in Angew Chem Int Ed Engl and referenced in Journal of Analytical & Bioanalytical Techniques

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