alexa ITGCN of the testis, contralateral testicular biopsy and bilateral testicular cancer
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Michael E Karellas, Ivan Damjanov, Jeffery M Holzbeierlein

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Over 30 years ago Skakkebaek was the first to characterize a noninvasive precursor lesion (intratubular germ cell neoplasia or carcinoma in situ) that would progress to invasive testicular tumors. In this article we discuss the molecular changes thought to cause this malignant transformation, various conditions that predispose to the development of testicular germ cell tumors, diagnostic strategies, and treatment options. Additionally we discuss the current patterns of contralateral testicular biopsy to identify intratubular germ cell neoplasia, as well as the incidence and

This article was published in Urol Clin North Am and referenced in Journal of Stem Cell Research & Therapy

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