alexa Japonicones Q-T, four new dimeric sesquiterpene lactones from Inula japonica Thunb.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Zhu JX, Qin JJ, Jin HZ, Zhang WD

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Abstract Four new dimeric sesquiterpene lactones (japonicones Q-T, 1-4) were isolated from the aerial part of Inula japonica Thunb., together with two known ones. Their structures were determined mainly by 1D and 2D NMR spectroscopic techniques including HSQC, (1)H-H COSY, HMBC, and NOESY. Herein, the inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages of 1-6 were evaluated; IC(50) values were tested as 8.5, 8.9, 4.3, 4.3, 4.2, and 9.2μM, respectively. Copyright © 2012 Elsevier B.V. All rights reserved. This article was published in Fitoterapia and referenced in Journal of Molecular and Genetic Medicine

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