alexa Jaundice in falciparum malaria; changing trends in clinical presentation--a need for awareness.

Author(s): Ahsan T, Ali H, Bkaht SF, Ahmad N, Farooq MU,

Abstract Share this page

Abstract OBJECTIVES: To describe the clinical characteristics, laboratory parameters and prognostic factors in patients with falciparum malaria (FM) with jaundice. METHODS: A cross-sectional comparative study was conducted at the Department of Medicine, medical unit II, Jinnah Postgraduate Medical Centre, Karachi. Adult patients with jaundice and smear positive plasmodium falciparum infection, who fulfilled the inclusion criteria were selected for the study from amongst all cases of FM who presented during the study period. Patients were divided in to two groups on the basis of rising bilirubin and adverse outcome. The data was analyzed on SPSS ver 12. Results were expressed as, percentages, mean and standard deviations. P-value < 0.05 was taken as significant. RESULTS: Among 76 patients of FM, 35 (46.05\%) developed jaundice. Fifteen (42.86\%) patients had bilirubin 3-10 mg/dl while 20 (57.14\%) had bilirubin > 10 mg/dl. Comparative analysis of the groups showed that elevation of ALT and AST was modest in comparison with conjugated hyperbilirubinaemia while prolonged duration of illnes impaired consciousness, hepatomegaly, acute renal failure with deranged renal parameters, low platelet counts and high parasite density were significantly associated with rising bilirubin and adverse outcome. Twenty-one (60\%) patients recovered completely while 14(40\%) succumbed to the disease. CONCLUSION: FM is one of the causes of severe jaundice in adults in this part of the world. This presentation of complicated FM needs to be recognized globally in order to institute prompt and specific therapy. Delayed diagnosis and inappropriate treatment is the leading cause of complications and increased mortality in FM.
This article was published in J Pak Med Assoc and referenced in

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Recommended Journals

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords