alexa JNK signaling in apoptosis.
Immunology

Immunology

Journal of Cell Signaling

Author(s): Dhanasekaran DN, Reddy EP

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Abstract Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and antiapoptotic proteins through distinct phosphorylation events. This review analyses our present understanding of the role of JNK in apoptotic signaling and the various mechanisms by which JNK promotes apoptosis.
This article was published in Oncogene and referenced in Journal of Cell Signaling

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